New Genetic Regulators of Brain Metastases in Lung Cancer Discovered

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Research [..] has identified new regulators of brain metastases in patients with lung cancer. These regulators are the genes called SPOCK1 and TWIST2.
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"Brain metastases are a secondary brain tumour, which means they are caused by cancer cells that escape from primary tumours like lung, breast or melanoma, and travel to the brain," [..]. "We set out to find which genes can regulate the cells that initiate brain metastases, which we've termed brain metastasis initiating cells or BMICs. In other words, what are the genes that are sending the signal to these lung BMICs to leave a lung tumour, go into the blood stream, invade the blood-brain barrier and form a tumour in the brain."
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The study used samples from lung cancer patients with brain metastases. The samples were incubated to enrich for BMICs, then injected into the lungs, hearts and brains of mice. The subsequent development of brain metastases was studied by researchers.
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"If you can identify the genes that cause metastases, then you can determine a predictive model and you can work towards blocking those genes with possible treatments,".
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News Reference  New Genes Discovered Regulating Brain Metastases In Lung Cancer

2 comments:

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