This Single Genetic Change May Increase Tuberculosis Susceptibility

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Biotechnology lab in Nigeria


Chinese researchers have found that a single change in a gene may increase the risk of tuberculosis.

According to the study, a single nucleotide change in a gene that affects the production of hepcidin-- a peptide involved in inflammation, immunity, and control of iron levels--is associated with greater susceptibility to extrapulmonary tuberculosis situated or occurring outside the lungs.

Individuals with this single nucleotide polymorphism (SNP) make significantly less hepcidin in response to infection by Mycobacterium tuberculosis.

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They proposed that decreased hepcidin production in response to infection and inflammation reduces the ability of macrophages to destroy M. tuberculosis, which then enters the circulation and spread the infection from the lungs to other areas of the body.

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Read full & original post Genetic variation may increase tuberculosis susceptibility

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